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Electrophysiological studies involve patch-clamp recordings in cortical neurons, transfected cell lines, and brain tissue slices. We employ molecular techniques to alter ion channels and signaling components important in cell death processes. The laboratory currently operates three complete patch-clamp rigs and one slice rig, all equipped with fluorescent microscopes for identification of transfected cells.

 

 

 

 

Redox modulation of the NMDA receptor
 
Aizenman et al. Neuron 2:1257-1263 (1989)